In studying wisdom-seeking as a cultural endeavor, I seek to describe the development of influential ‘wisdom frameworks’ over time. This study begins with a formal definition of wisdom as a holistic, transmittable program for human flourishing that derives authoritative prescriptions from a shared understanding of what is real, ultimate, and good: a program, in other words, that unites the metaphysical, the intellectual, and the ethical. I aim to see how wisdom programs were construed and enacted in Western thought and to learn, specifically, how concepts of data, information, and knowledge function within these programs.